Replay value wise...

Legend of Mana has story line in events and it is almost impossible to get 100% completion of all events without at least beating it once.

Saga Frontier has seven characters with different story lines and so it has seven playthroughs with special bonus at the end... Although, I've never seen the bonus...

Resident Evil 4 for the Wii is so entertaining much less getting extra things like Ada's storys and Mercenaries.