Oh man, bobobo (it prob has like 6 more b's and o's at least) def takes the cake for that. Although that mini gundam one was pretty disgraceful to an awesome series as well. Gundam SD or something I think?
End of Evengelion was twisted. Sorcerer Hunters was cool but really wierd, theres characters named Carrot, Chocolate, in one of the episodes theres a character named Sandwich. It got me because the first 12 episodes are funny and the last 12 are just twisted.
mahou sensei negima, it puts school girls/magic/ninjas/vampires/robots/talking animals/time travelling aliens/panty upskirt shots together. not much of a story either
Raxephon deserves a mention sololy because its so mind numbingly complex (in a intellectual way) as does the ghost in shell series although both these animes are really really good
finally we reach the anime that ppl will agree is a big WTF: bobobo
i swear to god some of the scenes seriously dont make any sense. the assassin guy who wears nothing but a duck underwear, only to have the duck underwear come to life and swear the hell at all the characters, and then the duck underwears father appears from bobobos head and explains the duck underwears life story...
wtfness... nuff said