Kyon & Haruhi from Suzumiya Haruhi no Yuuutsu. They're a fun couple.

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--C.D.--

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"Cats regard people as warm-blooded furniture." --Jacquelyn Mitchard

Naruto And Sakura From Naruto.
Even Though Sakura Isnt Really Interested In Naruto Since He's An Idiot..
Someday She'll Realize His Love For Her! They Make A Sweet Couple. <3
There's Another Character Who's Obsess With Sakura And His Name Is Rock Lee.
And Sakura Is Obsess/Addicted To The Other Main Character Name Sasuke. Naruto's Friend Who He's Share A Bond With Finally.

I would have to say Ash and Misty from pokemon.

depends if its an real couple or a fan made one

Horo and Lawrence from Spice and wolf :3

Shuichi, and Yuki from Gravitation!

Mako and Iketani from Initial D. I only hope they get together at the end of the series.

Inuyasha and Kagome.

Naruto and Hinata.

Chun-Li and Ryu from the Street Fighter series.

Terry and Mai from KOF, even though they like different people, I always thought they make a good pair since they are like the main characters, or the favorites, in the series,

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Sana and ... her mate(ugh,,, I forgot his name) -Kodomo no Omocha

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Does Pokemon count as anime? Cause I would choose Team Rocket...hehe

Hmm. Can I list favorites?

Integra and Alucard
Yuuki and Touya
Sora and BT *dies*
Tatsumi and Watari

And those are the top ones right now.