Hands down, The uber version of Gravity Fun from HL2, i mean com'on, what's there NOT to like about it.
If you were offered one, there's no way you could reject it.
Too amazing.
Sour cream. If you cram enough of it into somebody's throat....
Actually... video game wise, it'd have to be the enemies from Kirby's Adventure. Or maybe it's Kirby's stomach... whatever that allows him to gain powers from others.